Phospholipid phosphatase 2 supports liver healing and regrowth after sudden liver damage

Phosphatidylethanolamine undergoes dynamic metabolic reprogramming during liver regeneration, with phospholipid phosphatase 2 (PLPP2) showing significant changes.

• The specific metabolic shift that initiates liver cell regeneration remains unclear, despite the liver's known regenerative capacity.
• Alterations in PLPP2 were observed in liver biopsy samples from patients with drug-induced liver injury.
• In mouse models, the deletion of PLPP2 in liver cells worsened acute liver injury.
• During liver regeneration, the resolution of endoplasmic reticulum (ER) stress was linked to an increase in PLPP2 levels.
• Phosphatidylethanolamine supports liver repair by binding to PEBP1, enhancing its interaction with GLI1, which prevents the degradation of GLI1.
• PE also promotes autophagy by aiding the lipidation of LC3B and helps alleviate ER stress through increased ER-localized PE.

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