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Photo‐crosslinked gelatin‐hyaluronic acid methacrylate hydrogel‐committed nucleus pulposus‐like differentiation of adipose stromal cells for intervertebral disc repair
Using light-activated gelatin and hyaluronic acid gel to guide fat-derived stem cells into disc-like cells for repairing spinal discs
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Abstract
The combination of GelHA hydrogel and adipose stromal cells resulted in significantly higher disc height index in a rat model of intervertebral disc degeneration.
- GelHA hydrogel promoted nucleus pulposus-like differentiation of adipose stromal cells (ASCs).
- Integrin αvβ6 neutralising antibody inhibited the expression of nucleus pulposus matrix by ASCs in vitro.
- The use of GelHA hydrogel with ASCs resulted in improved intervertebral disc repair in rats.
- The approach led to an increase in the presence of nucleus pulposus matrix in the repaired discs.
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