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Different mechanisms of adjustment to a change of the photoperiod in the suprachiasmatic and liver circadian clocks
Different ways the brain’s main clock and the liver’s clock adjust to changes in day length
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Abstract
Clock gene expression rhythms in the mouse suprachiasmatic nucleus (SCN) and liver adjust to changes in photoperiod from 18 hours of light to 6 hours.
- The clock gene expression rhythms in various regions of the SCN became synchronized over time after the transition to a shorter photoperiod.
- Desynchronization was observed under long photoperiod conditions, which gradually resolved following the switch to short days.
- The adjustment in the SCN involved not just synchronization but also different patterns of rhythm expression in its individual parts.
- Locomotor activity rhythms shifted gradually, with activity onset occurring earlier in response to shorter light periods.
- Liver clock rhythms adjusted by an earlier rise in Rev-erbalpha expression and a shift in Per2 decline.
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