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Phytosphingosine contributes gut microbiota metabolism to alleviate low-grade endotoxemia-induced mastitis
Phytosphingosine helps gut bacteria reduce mild inflammation-linked mastitis
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Abstract
Cows with SARA-associated mastitis exhibited a reduced level of (PS) compared to healthy cows.
- Altered ruminal metabolic profiles were observed in cows with SARA-associated mastitis.
- Oral administration of PS to mice reduced mammary injury and improved the function of mammary tight junctions.
- induced significant gut dysbiosis, increasing opportunistic pathogens such as Enterococcus, which was alleviated by PS treatment.
- Transplantation of fecal microbiota and sterile supernatant from PS-treated mice restored the blood-milk barrier and modulated gut microbiota in recipient mice.
- PS and PS-FMT treatments increased fecal short-chain fatty acid (SCFA) producers and elevated levels of butyric acid.
- Butyric acid levels were negatively correlated with mammary inflammatory markers, and its administration reduced LGE-induced mastitis in mice.
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Key numbers
133.9×
Decrease in Level
Comparison of levels in cows with SARA-associated mastitis vs. healthy cows.
5 μg/mouse
Reduction in TNF-α Levels
TNF-α levels in mammary glands after treatment in -induced mastitis model.