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Abstract
Pink1 deletion in mice leads to decreased ovarian weight and impaired fertility.
- Loss of Pink1 is associated with diminished ovarian reserve and reduced oocyte quality.
- Increased granulosa cell apoptosis and accelerated ovarian ageing are observed with Pink1 deficiency.
- Pink1 deficiency compromises ovulation efficiency and increases oocyte cytoplasmic fragmentation.
- Disruption of meiotic spindle assembly occurs, resulting in reduced developmental competence of early embryos.
- RNA sequencing indicates that loss of Pink1 impairs mitophagy and promotes signs of ovarian ageing.
- Parkin deletion shows minimal effects on mitophagy, mitochondrial function, or ovarian physiology.
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