PINK1 and STUB1 pathway orchestrates peroxisomal selective autophagy by PEX13 depletion

PINK1 is identified as a key regulator of pexophagy, particularly in response to PEX13 depletion.

• Selective autophagy, known as pexophagy, helps maintain peroxisome quality by removing damaged or excess peroxisomes.
• A novel signaling cascade involving ATM, PINK1, STUB1, ABCD3, and SQSTM1 is proposed to regulate pexophagy during peroxisomal impairment.
• PINK1 phosphorylates STUB1, which increases its activity to ubiquitinate ABCD3, facilitating the recruitment of SQSTM1 for peroxisomal degradation.
• ATM is shown to activate PINK1 when peroxisomal stress occurs, connecting cellular stress responses with organelle quality control.

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