Pirfenidone may improve metabolic hormones and heart cell cleanup through p-AMPK in fatty liver-related heart disease

Obesity is commonly associated with cardiovascular disease and may disrupt key metabolic hormones.

• Chronic inflammation and insulin resistance are promoted by obesity.
• Disruption of hormones like insulin and leptin is linked to metabolic dysfunction in MASH.
• Autophagy plays a role in preserving heart function under stress.
• Pirfenidone is an antifibrotic and anti-inflammatory drug that has not been studied for its effects on metabolic hormones in MASH.
• The relationship between Pirfenidone, cardiac autophagy, and metabolic regulation in MASH remains unexplored.

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