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Associations between plasma beta amyloid and cognitive decline: A systematic review and meta-analysis
Links between blood beta amyloid levels and mental decline: A review and combined analysis
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Abstract
A total of 25 studies were included in the systematic review, with four contributing to the meta-analysis.
- The lower plasma Aβ-42/Aβ-40 ratio was not significantly associated with Alzheimer's disease risk (pooled HR=0.8; 95% CI: 0.62-1.04).
- Substantial heterogeneity was observed among the studies (I²=70%, p=0.02).
- Individual studies showed conflicting results: some indicated that a lower Aβ-42/Aβ-40 ratio predicted increased Alzheimer's disease risk, while others reported no association or opposing trends.
- Methodological differences, including sample handling and measurement techniques, may have contributed to the variability in findings.
- The review suggests that the plasma Aβ-42/Aβ-40 ratio is not a reliable predictor for the onset of Alzheimer's disease or dementia.
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Key numbers
0.8
Pooled for
Pooled from four studies included in the .
25
Study Count
Total studies evaluated for plasma Aβ and cognitive decline.