Imbalance of Plasma Copper and Zinc Levels and the Association Between the Cu/Zn Ratio and Lipid Peroxidation in Algerian Bipolar Patients

Sep 19, 2023Biological trace element research

Imbalance of Blood Copper and Zinc Levels and Their Link to Cell Damage in Algerian Bipolar Patients

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Abstract

Plasma copper concentrations were higher in patients with bipolar disorder compared to healthy controls (p < 0.05).

Zinc levels were significantly lower in patients with bipolar disorder than in healthy controls.
The Cu/Zn ratio was significantly different between the two groups.
No significant difference in the marker of plasma lipid peroxidation (Malondialdehyde: MDA) was observed between patients and controls.
A negative correlation was found between MDA and the Cu/Zn ratio in patients (r= -0.38, p= 0.027).
An elevated Cu/Zn ratio may be associated with reduced lipid peroxidation in patients with bipolar disorder.

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Trace elements, through their interaction with biomolecules, can play an important role in the pathophysiology of bipolar disorder and protect against oxidative stress effects. The purpose of this study is to examine plasma concentration levels of zinc (Zn) and copper (Cu) of Algerian patients, diagnosed with bipolar disorder, and to compare these levels with those of healthy controls. The Cu/Zn ratio was calculated to explore a possible correlation between these elements and lipid peroxidation in the study groups. A total of 33 patients diagnosed with bipolar disorder and 38 healthy subjects participated in this study. Plasma copper and zinc concentrations were measured using a polarographic analyzer. The marker of plasma lipid peroxidation (Malondialdehyde: MDA) was determined by UV spectrophotometry. Plasma Cu concentrations were higher in patients compared to controls (p < 0.05), while the Zn level was significantly lower. Consequently, the Cu/Zn ratio was significantly different between patients and controls. Regarding MDA, no significant difference was noticed between the two study groups. However, in patients, a negative correlation was found between MDA and Cu/Zn ratio (r= -0.38, p= 0.027). These results suggested that an elevated Cu/Zn ratio is associated with attenuated lipid peroxidation in our bipolar patients.

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Imbalance of Plasma Copper and Zinc Levels and the Association Between the Cu/Zn Ratio and Lipid Peroxidation in Algerian Bipolar Patients

Abstract

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