Neurobiology of disease

Blood levels of PINK1/Parkin ratio and ATF5 linked to movement problems in Parkinson's disease

Updated

Abstract

Motor complications, particularly dyskinesia, affect many Parkinson's disease patients within years of levodopa therapy.

  • Reliable biomarkers for motor complication subtypes in Parkinson's disease are currently lacking.
  • Mitochondrial quality control pathways may play a significant role in the development of Parkinson's disease.
  • The relationship between these mitochondrial pathways and motor complications is not yet fully understood.

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