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Daily Profiles of Plasma Prolactin (PRL), Growth Hormone (GH), Insulin‐Like Growth Factor‐1 (IGF‐1), Luteinizing Hormone (LH), Testosterone, and Melatonin, and of Pituitary PRL mRNA and GH mRNA in Male Long Evans Rats in Acute Phase of Adjuvant Arthritis
Daily changes in key hormones and their gene activity in male rats during early arthritis
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Abstract
Adjuvant arthritis significantly alters the 24-hour hormonal rhythms in male Long Evans rats, impacting prolactin, luteinizing hormone, and insulin-like growth factor-1 levels.
- Prolactin and its mRNA displayed significant 12-hour rhythms in control rats, with peaks at 14:00 h and 02:00 h, while this pattern was disrupted in the AA group.
- A 24-hour rhythm of prolactin and its mRNA was observed in the AA group, indicating a shift in hormonal regulation.
- Growth hormone showed no rhythmic pattern, but growth hormone mRNA exhibited significant rhythmicity in both control and AA rats.
- Insulin-like growth factor-1 demonstrated a 24-hour rhythm in controls but not in AA rats, suggesting impaired hormonal regulation.
- Luteinizing hormone had a significant 24-hour rhythm peaking during the dark period in controls, which was abolished in the AA group.
- Melatonin maintained a significant 24-hour rhythm in both groups, with higher mesor values in AA males, indicating that the pineal gland function remains intact despite other hormonal disruptions.
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