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Daily changes in key hormones and their gene activity in male rats during early arthritis
Updated
Abstract
Adjuvant arthritis significantly alters the 24-hour hormonal rhythms in male Long Evans rats, impacting prolactin, luteinizing hormone, and insulin-like growth factor-1 levels.
- Prolactin and its mRNA displayed significant 12-hour rhythms in control rats, with peaks at 14:00 h and 02:00 h, while this pattern was disrupted in the AA group.
- A 24-hour rhythm of prolactin and its mRNA was observed in the AA group, indicating a shift in hormonal regulation.
- Growth hormone showed no rhythmic pattern, but growth hormone mRNA exhibited significant rhythmicity in both control and AA rats.
- Insulin-like growth factor-1 demonstrated a 24-hour rhythm in controls but not in AA rats, suggesting impaired hormonal regulation.
- Luteinizing hormone had a significant 24-hour rhythm peaking during the dark period in controls, which was abolished in the AA group.
- Melatonin maintained a significant 24-hour rhythm in both groups, with higher mesor values in AA males, indicating that the pineal gland function remains intact despite other hormonal disruptions.
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