We can’t show the full text here under this license.
Blood protein Alzheimer's risk score linked to biological aging and disease progression timing
Updated
Abstract
Essence
Plasma proteomic aging clocks and pseudotime trajectories may complement Alzheimer's disease biomarkers and diagnostic classification.
Evidence
An observational plasma proteomics analysis of 498 Indiana AD Research Center participants used SomaScan 7k data to test Alzheimer's risk scores against diagnosis, plasma biomarkers, imaging biomarkers, and classification performance.
Caveat
The abstract reports association and classification performance in one research-center dataset, so clinical use would need external and prospective validation.
Simplified
Key numbers
498
Participants
Total participants from the Indiana Alzheimer's Disease Research Center cohort.
22%
- improvement
Increase in - for vs. classification when incorporating and cognition-optimized age measures.