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Abstract
CD8+ T cell senescence may be a major contributor to the immunosuppressed state in patients with chronic kidney disease (CKD).
- Platelets derived from CKD patients may induce premature CD8+ T cell senescence.
- This induction could occur through the mediation of mitochondrial dysfunction.
- Platelet-derived microparticles (PMPs) from CKD patients promote CD8+ T cell senescence by transferring miR-550a-5p.
- The transfer of miR-550a-5p decreases PMPCB expression and induces failure in NDUFS8 cleavage.
- Inhibition of miR-550a-5p and pretreatment with nicotinamide mononucleotide may prevent platelet-induced CD8+ T cell senescence.
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