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Abstract
The most stable terpolymer shows transfection efficacy several times higher than polyethylenimine when injected intravenously in mice.
- Novel ionizable terpolymers were designed using a combination of specific polymerization techniques.
- The ability to deliver mRNA is influenced by the material's physiochemical properties, including lipophilicity.
- Formulation methods for complexing the polymer with oligonucleotides are identified as a previously unstudied factor in nucleic acid delivery.
- The terpolymer's focused delivery to the spleen suggests potential applications in cancer immunotherapy and vaccination.
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