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Abstract
Polyethylenimine (PEI) is highlighted as a promising platform for RNA delivery due to its versatile properties.
- PEI shows strong binding capacity for nucleic acids and efficient endosomal escape.
- Stimuli-responsive PEI systems are classified by both endogenous triggers, like pH and reactive oxygen species, and exogenous stimuli, such as light and temperature.
- Reported strategies for enhancing PEI systems include chemical modification and hybridization with inorganic nanomaterials.
- These advancements aim to improve specificity, transfection efficiency, and biocompatibility while reducing cytotoxicity.
- Dual- and multistimuli-responsive designs allow for controlled release, potentially enhancing therapeutic efficacy in both laboratory and living systems.
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