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Polyphenol-Loaded Plant Extracellular Vesicles: A New Approach to Combat AGEs-Induced Neurotoxicity via the Microbiota-Gut-Brain Axis
Plant Particles Carrying Polyphenols May Help Reduce Brain Damage from Harmful Sugar Compounds Through Gut Microbiome Interaction
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Abstract
Excessive dietary intake of advanced glycation end products (AGEs) is a potential risk factor for neurodegenerative diseases.
- AGEs may impair the intestinal barrier and disturb gut microbiota balance.
- This impairment could trigger neuroinflammation and oxidative stress through the microbiota-gut-brain axis.
- Plant extracellular vesicles (PEVs) can enhance the absorption of polyphenols and may work together with them to provide health benefits.
- PEVs may exhibit antioxidant and anti-inflammatory properties while modulating the gut environment.
- PEVs-polyphenols delivery systems could potentially reduce AGEs-related neurotoxicity by supporting microbiota-gut-brain axis function.
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