La Tunisie medicaleMar 25, 2026

Polyphenols as Epigenetic Influencers for Preventing and Treating Chronic Diseases

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Mar 27, 2026

Abstract

Polyphenols such as resveratrol, curcumin, quercetin, and catechins may exert protective actions by influencing gene expression.

Polyphenols are linked to the modulation of epigenetic mechanisms associated with chronic diseases.
Key epigenetic processes impacted by polyphenols include DNA methylation, histone modifications, and microRNA regulation.
These compounds could counteract harmful epigenetic changes that contribute to chronic conditions.
Understanding the role of polyphenols in epigenetics may facilitate the development of new therapeutic approaches.

Simplified

BACKGROUND: The rising prevalence of chronic diseases, including cancer, metabolic disorders, neurodegenerative, and cardiovascular conditions, presents a growing challenge to modern medicine and public health.

AIM: This article investigates the potential of polyphenols as modulators of epigenetic mechanisms in the context of chronic disease.

METHODS: A comprehensive review of scientific literature was conducted, with emphasis on key epigenetic processes such as DNA methylation, histone modifications, and microRNA regulation.

RESULTS: Polyphenols like resveratrol, curcumin, quercetin, and catechins exert protective actions by modulating gene expression, counteracting harmful epigenetic changes, and supporting cellular health.

CONCLUSION: Advancing our understanding of how polyphenols influence epigenetic pathways may lead to innovative therapeutic strategies combining conventional and personalized approaches.

Polyphenols as Epigenetic Influencers for Preventing and Treating Chronic Diseases

Abstract

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