Full text is available at the source.
Abstract
Mitochondrial remodeling is linked to chemotherapy resistance in gastrointestinal cancers.
- Chemotherapy resistance in GI cancers is influenced by mitochondrial changes.
- Key processes in mitochondrial remodeling include metabolic reprogramming and increased apoptotic thresholds.
- Alterations in reactive oxygen species levels may play a role in chemoresistance.
- Mitophagy, a process for maintaining mitochondrial quality, is also associated with these resistance mechanisms.
- Polysaccharides and their systems could potentially help address mitochondrial dysfunctions due to their varied structures and favorable biological properties.
Simplified