Portioning organelles for autophagic clearance

All known mammalian and yeast organellophagy receptors expose their LIR within intrinsically disordered regions.

• Organellophagy is mediated by receptors that respond to various stimuli, including nutrient deprivation and pathogen invasion.
• Activation of organellophagy receptors drives the clearance of damaged organelles through autophagy.
• The intrinsically disordered regions of organellophagy receptors are necessary for organelle fragmentation at their membranes.
• LC3 engagement is crucial for the lysosomal delivery of organelles but is not required for their initial fragmentation.
• The findings suggest the potential for developing therapies that utilize controlled organelle fragmentation.

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