Expanding Biological Roles of Post-translational Arginylation

Protein arginylation is a key global regulator of cellular functioning.

• Arginylation involves the addition of arginine residues to proteins by arginyl-tRNA transferase.
• It has established roles in protein degradation via the Ubiquitin-Proteasome System and Autophagy-Lysosome System.
• Recent findings indicate its broader regulatory influence on protein-protein interactions and complex assembly.
• Arginylation is associated with changes in protein stability and interactions with other post-translational modifications.
• Emerging evidence suggests that the effects of arginylation may vary depending on the cellular context.

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