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PRD-2 mediates clock-regulated perinuclear localization of clock gene RNAs within the circadian cycle of Neurospora
PRD-2 controls daily timing of clock gene RNA positioning near the nucleus in Neurospora
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Abstract
The fraction of nuclei actively transcribing clock genes changes in a circadian manner with fewer than five transcripts per nucleus at any time.
- Circadian clocks in animals and fungi exhibit similar molecular regulatory structures.
- Clock messenger RNAs (mRNAs) accumulate rhythmically with a significant delay before the corresponding proteins appear.
- Spatial analysis indicates that mRNAs cluster around nuclei in a time-of-day-dependent manner.
- The clustering of mRNAs requires the RNA-binding protein .
- PRD-2 may facilitate the organization of clock mRNAs for local translation and protein complex assembly.
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Key numbers
6
Transcripts per nucleus at peak times
Observed in early subjective morning.
32%
Active transcription nuclei percentage
Measured during the subjective morning.