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Children's immune profiles before vaccination linked to their COVID-19 vaccine response
Updated
Abstract
Twenty-one participants with inborn errors of immunity were stratified as high or low vaccine responders based on anti-SARS-CoV-2 spike IgG titers at day 28 post-vaccination.
- Low responders had significantly lower frequencies of switched memory B cells compared to high responders.
- Forty-one genes showed different expression levels between high and low responders at baseline.
- High responders demonstrated greater induction of genes related to activation and memory in specific immune cells.
- Distinct pre-vaccination gene expression patterns are associated with varied humoral responses to mRNA vaccination in this population.
- Baseline molecular immune characteristics may influence vaccine effectiveness in individuals with compromised immunity.
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