Prebiotic raffinose reduces surgery-related delirium-like behavior by changing gut bacteria and serotonin signaling in frail aging mice

Preoperative administration of raffinose may prevent postoperative delirium in frail senescence-accelerated mice.

• Postoperative delirium is associated with acute cognitive dysfunction and neuroinflammation, particularly in older adults.
• The gut-brain axis may play a role in regulating neuroinflammation.
• Raffinose is a prebiotic that may influence gut microbiota.
• The study aims to explore the potential of raffinose in modulating neuroimmune responses to prevent delirium-like behaviors.

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