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Effects of prebiotics on intestinal physiology, neuropsychological function, and exercise capacity of mice with sleep deprivation
Prebiotics' effects on gut health, brain function, and exercise ability in sleep-deprived mice
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Abstract
Sleep deprivation caused intestinal inflammation and decreased tight junction gene expression in male mice.
- Sleep deprivation is associated with increased intestinal inflammation, indicated by elevated levels of TNFA and IL1B.
- There was a significant decrease in the expression of tight junction genes (OCLN, CLDN1, TJP1, and TJP2) in the intestine and brain due to sleep deprivation.
- Supplementation with a prebiotic mixture of short-chain galactooligosaccharides and long-chain fructooligosaccharides increased levels of beneficial short-chain fatty acids, such as acetate and butyrate.
- Prebiotics improved the expression of clock and tight junction genes in the hypothalamus and hippocampus, which may help mitigate anxiety and depression linked to sleep deprivation.
- Prebiotics also had a positive impact on blood sugar regulation and exercise performance, suggesting potential benefits for health maintenance.
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