Prebiotics, Probiotics, and Postbiotics in Modulating Gut Microbiota: Emerging Therapeutic Approaches for Metabolic Syndrome

Emerging therapeutic strategies for managing Metabolic Syndrome (MetS) focus on modulating gut microbiota using prebiotics, probiotics, and postbiotics.

• Biotics may exert pharmacological effects by restoring gut health and managing MetS through modulation of various gut-system axes.
• They could influence satiety regulation, insulin sensitivity, bile acid metabolism, systemic inflammation, and overall energy homeostasis.
• Prebiotics serve as substrates to stimulate beneficial bacteria, while probiotics supplement the gut with live microorganisms.
• Postbiotics are bioactive microbial byproducts that may directly influence host metabolism.
• Conventional therapies for MetS often target individual conditions rather than the syndrome as a whole, which may lead to adverse drug reactions.
• Biotic interventions may improve insulin sensitivity, reduce inflammation, regulate appetite, and modulate lipid and bile acid metabolism.

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