Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence Markers

May 1, 2024Hypertension (Dallas, Tex. : 1979)

Women Who Had Preeclampsia Show Faster Aging and Higher Levels of Aging-Related Markers

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Abstract

Women with a history of preeclampsia have a 4× higher risk of developing major cardiovascular events compared to those with normotensive pregnancies.

Preeclampsia is associated with unfavorable aging profiles, including decreased urinary α-Klotho and increased leptin levels.
Higher leptin/adiponectin ratios and increased extracellular vesicles positive for tissue factor were observed in women with a history of preeclampsia.
A greater rate of comorbidities was reported at enrollment for women with a history of preeclampsia.
Results suggest that cellular senescence may contribute to accelerated aging in women who experienced preeclampsia.

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BACKGROUND: Senescence, a mechanism of cellular aging, which is characterized by irreversible proliferation arrest and a proinflammatory secretory phenotype, has been documented in women with preeclampsia. As cellular senescence can persist and progress, we postulated that it is associated with accelerated aging phenotype and accumulation of comorbidities in women with a history of preeclampsia.

METHODS: We included a cohort of women with a history of preeclampsia (n=40) age- and parity-matched to a group of referent women with normotensive pregnancies (n=40). Women with prior major cardiovascular events, neurological, or autoimmune conditions were excluded. We collected urine and blood samples to study markers of aging, data on multimorbidity at the time of enrollment, and prospectively followed them for events over the course of 6 years, on average.

RESULTS: Women with a history of preeclampsia exhibited unfavorable aging profiles compared with referent women, including decreased urinary α-Klotho (=0.018); increased leptin (=0.016) and leptin/adiponectin ratio (=0.027), and increased extracellular vesicles positive for tissue factor (=0.025). Women with a history of preeclampsia likewise had a higher rate of comorbidities at the time of enrollment (=0.003) and had a 4× higher risk of developing major cardiovascular events compared with referent women (=0.003). P P P P P P

CONCLUSIONS: Our data suggest that a history of preeclampsia is associated with accelerated aging as indicated by senescence marker differences and the accumulation of multimorbidity later in life. Targeting cellular senescence may offer novel, mechanism-based approaches for the diagnosis and treatment of adverse health outcomes in women with a history of preeclampsia.

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Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence Markers

Abstract

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