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Detrimental effect of prenatal progesterone exposure on anxiety and depressive-like responses in adult male and female rat offspring: Role of plasma, hippocampal corticosterone and hippocampal progesterone receptors
Prenatal progesterone exposure linked to anxiety and depression-like behavior in adult male and female rats, related to stress hormones and hormone receptors in the brain
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Abstract
Prenatal exposure to progesterone at low and high doses (10 and 50 mg/kg) induces anxiogenic and depressive-like effects in adult rat offspring.
- Behavioral tests revealed increased anxiety and depressive-like behaviors in both male and female offspring exposed to prenatal progesterone.
- Elevated plasma and hippocampal corticosterone levels were observed in adult offspring following prenatal progesterone treatment.
- Increased expression of progesterone receptors was measured in the hippocampus of both sexes after prenatal exposure to progesterone.
- These findings suggest that prenatal exposure to progesterone may lead to long-term emotional disturbances linked to hormonal changes.
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