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Abstract
Chronic neuroinflammation, oxidative stress, and disrupted cellular homeostasis are critical issues in neurodegenerative disorders.
- Polyamines, including putrescine, spermidine, and spermine, are important for neuronal function and protection against cellular stress.
- Spermidine-induced autophagy is linked to increased neuronal longevity and cognitive resilience.
- Probiotics and specific gut microbes can influence host polyamine production through the gut-brain axis.
- Microbial modulation may restore polyamine balance and enhance antioxidant defenses while reducing neuroinflammation.
- Targeting microbiota-driven polyamine synthesis could represent a non-invasive strategy for neuroprotection.
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