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Probiotic Spore-Based Oral Delivery to Improve Pancreatic Cancer Chemotherapy through the Gut-Pancreas Connection
Updated
Abstract
Intratumoral drug accumulation is increased by approximately 3-fold using a probiotic spore-based oral drug delivery system.
- A probiotic spore-based system enhances chemotherapy effectiveness for pancreatic cancer by utilizing the gut-pancreas connection.
- The delivery system involves spores that are resistant to harsh conditions, serving as carriers for gemcitabine-loaded nanoparticles.
- In mouse models of pancreatic ductal adenocarcinoma, tumor growth is significantly reduced with the spore-based delivery system.
- No significant side effects are observed with the use of the probiotic oral drug delivery system.
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