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Probiotic supplementation on cognitive and other aging-related physiological functions in middle-aged and older adults with mild cognitive impairment (PCAMCI): protocol for a randomized, triple-blinded, placebo-controlled trial
Probiotics and their effects on thinking and aging body functions in middle-aged and older adults with mild memory problems
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Abstract
A total of 110 participants aged 55-80 years with will be involved in a clinical trial assessing the effects of probiotic supplementation.
- Probiotic supplementation will consist of three specific strains: Lactiplantibacillus plantarum ST-III, Lacticaseibacillus rhamnosus KF7, and Lacticaseibacillus paracasei BD5115.
- The primary outcome will evaluate cognitive function using the Montreal Cognitive Assessment (Chinese Beijing Version).
- Secondary outcomes will include digestive health, sleep quality, facial aging, vision and hearing function, body composition, bone density, and muscle strength.
- Brain imaging and wearable devices will be used to gather additional physiological data over the 12-month study period.
- The trial aims to explore how gut microbiota modulation may influence cognitive and physiological functions in adults with mild cognitive impairment.
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Key numbers
110
Participants Scheduled
Total number of middle-aged and older participants with .
55 to 80 years
Age Range
Age criteria for participant inclusion in the study.
12 months
Duration
Length of the probiotic supplementation .