Probiotics, gut microbiota, and brain health: Exploring therapeutic pathways.

Oct 13, 2025AIMS microbiology

How probiotics and gut bacteria may influence brain health and treatment

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Abstract

Psychobiotics may influence brain function through mechanisms like neurotransmitter production and neuroinflammation modulation.

  • The gut microbiome is involved in regulating gastrointestinal function and communication between the gut and brain.
  • Psychobiotics, a class of probiotics, have targeted neuroactive properties that could affect brain function.
  • These microorganisms may modulate neurotransmitter production, including GABA and serotonin.
  • Regulation of the hypothalamic-pituitary-adrenal (HPA) axis and vagus nerve signaling is associated with psychobiotics.
  • Applications of psychobiotics are being examined for neurological disorders such as Parkinson's disease and autism spectrum disorder.
  • Further research is necessary to confirm the effects of specific microbial strains and their long-term safety in clinical use.

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