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Reactive Oxygen-Triggered Lipid Nanoparticles Carrying Prodrugs for Improved mRNA Delivery and Combined Cancer Treatment
Updated
Abstract
LNP-Pro demonstrates significantly enhanced mRNA delivery efficacy compared to conventional formulations.
- LNP-Pro incorporates a camptothecin-based prodrug that is responsive to reactive oxygen species in tumor cells.
- This formulation shows superior delivery capacity in tumor cells compared to normal cells.
- In vitro and in vivo studies indicate that LNP-Pro synergizes with CPT chemotherapeutic to induce tumor cell apoptosis.
- Significant tumor growth inhibition is achieved in a murine model using LNP-Pro.
- The approach integrates stimulus-responsive prodrugs with lipid nanoparticle systems for mRNA-based cancer therapy.
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