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A bibliometric analysis of programmed cell death in oral cancer literature: research patterns and emerging trends (2000–2024)
Research trends and patterns in cell death studies related to oral cancer (2000-2024)
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Abstract
A total of 963 publications on in oral cancer were identified from 2000 to 2024.
- Annual publication output showed a steady increase, especially after 2010, indicating three distinct phases of research growth.
- The majority of publications originated from China (58.42%), followed by South Korea (12.27%) and Japan (10.04%).
- Research hotspots shifted from traditional apoptosis to emerging forms of programmed cell death, including autophagy, ferroptosis, and pyroptosis.
- Three major research clusters were identified: basic molecular mechanisms related to oxidative stress, clinical aspects such as prognosis and cell proliferation, and various cell death pathways.
- Emerging trends highlight the targeting of multiple programmed cell death pathways for oral cancer therapy, focusing on treatment resistance and patient survival.
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Key numbers
963
Publications Count
Total publications analyzed from 2000 to 2024
576 of 963
China's Contribution
Publications from China as a percentage of total
86
Annual Publication Peak
Highest number of publications in a single year