From Disease Worsening to Improvement: A New Way to Define Success in Long-Term Kidney Disease

Sustained preservation of estimated glomerular filtration rate and normalization of albuminuria may now be realistic goals in chronic kidney disease treatment.

• Recent trials have shown that remission in chronic kidney disease is increasingly attainable.
• Remission is defined as estimated glomerular filtration rate slopes of <1 ml/min per 1.73 m² per year or the absence of albuminuria with normal estimated glomerular filtration rate.
• Early detection and combination therapy could enhance the chances of achieving remission.
• A shift in nephrology's focus from delaying progression to maintaining kidney health is suggested.
• Population-based screening and guideline-directed therapy may be essential for scaling these advancements.

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