Combined microRNA and resveratrol treatment targeting cell regulators reverses obesity in high-fat diet mice

Prohibitin-targeted proton sponge nanovesicles demonstrated a 171.6 nm particle size and a +16.8 mV zeta potential.

• The nanovesicles effectively encapsulated a specific microRNA and protected it from degradation.
• In vitro tests indicated that the formulation was biocompatible and safe for cellular use.
• The treatment showed potential to downregulate fat cell development while upregulating metabolic markers.
• In vivo studies suggested that the nanovesicles are safe and could play a role in obesity treatment.
• The findings indicate a novel approach that combines gene silencing with metabolic regulation.

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