Blocking a specific receptor for Prostaglandin E2 improves movement problems and memory loss in a mouse model of Huntington's disease

Chronic administration of the EP1 receptor antagonist SC-51089 improved motor coordination and memory function in R6/1 mice with Huntington's disease.

• Motor dysfunction, assessed through rotarod, balance beam, and vertical pole tasks, was improved with SC-51089 treatment.
• Long-term memory deficits were alleviated as shown by enhanced performance in T-maze spontaneous alternation and novel object recognition tests.
• Treatment with SC-51089 increased the expression of specific synaptic markers in the brain regions affected by Huntington's disease.
• The number of huntingtin nuclear inclusions in the striatum and hippocampus decreased in 18-week-old R6/1 mice following treatment.
• Electrophysiological studies indicated that hippocampal long-term potentiation was significantly recovered after EP1 receptor antagonism.

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