Co-ingestion of protein or a protein hydrolysate with carbohydrate enhances anabolic signaling, but not glycogen resynthesis, following recovery from prolonged aerobic exercise in trained cyclists

Dec 8, 2017European journal of applied physiology

Adding protein or protein fragments to carbohydrates boosts muscle-building signals but not energy storage after long aerobic exercise in trained cyclists

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Abstract

In a study of 11 trained male cyclists, carbohydrate supplemented with protein increased anabolic signaling but did not enhance glycogen recovery.

Skeletal muscle glycogen resynthesis was not significantly different among carbohydrate (CHO), carbohydrate with intact protein (CHO-C), or carbohydrate with hydrolyzed protein (CHO-H) supplements.
CHO-H ingestion resulted in an increased insulin response compared to other supplements.
Both CHO-C and CHO-H led to significant increases in signaling molecules associated with protein synthesis compared to CHO alone.
CHO-H exhibited the greatest increase in a specific signaling molecule related to protein synthesis.
Protein co-ingestion during recovery did not improve glycogen resynthesis compared to carbohydrate alone.

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PURPOSE: The effect of carbohydrate (CHO), or CHO supplemented with either sodium caseinate protein (CHO-C) or a sodium caseinate protein hydrolysate (CHO-H) on the recovery of skeletal muscle glycogen and anabolic signaling following prolonged aerobic exercise was determined in trained male cyclists [n = 11, mean ± SEM age 28.8 ± 2.3 years; body mass (BM) 75.0 ± 2.3 kg; VO61.3 ± 1.6 ml kg min]. 2peak -1 -1

METHODS: On three separate occasions, participants cycled for 2 h at ~ 70% VOfollowed by a 4-h recovery period. Isoenergetic drinks were consumed at + 0 and + 2 h of recovery containing either (1) CHO (1.2 g kg BM), (2) CHO-C, or (3) CHO-H (1.04 and 0.16 g kgBM, respectively) in a randomized, double-blind, cross-over design. Muscle biopsies from the vastus lateralis were taken prior to commencement of each trial, and at + 0 and + 4 h of recovery for determination of skeletal muscle glycogen, and intracellular signaling associated with protein synthesis. 2peak -1 -1

RESULTS: Despite an augmented insulin response following CHO-H ingestion, there was no significant difference in skeletal muscle glycogen resynthesis following recovery between trials. CHO-C and CHO-H co-ingestion significantly increased phospho-mTOR Serand 4EBP1 Thrversus CHO, with CHO-H displaying the greatest change in phospho-4EBP1 Thr. Protein co-ingestion, compared to CHO alone, during recovery did not augment glycogen resynthesis. 2448 37/46 37/46

CONCLUSION: Supplementing CHO with intact sodium caseinate or an insulinotropic hydrolysate derivative augmented intracellular signaling associated with skeletal muscle protein synthesis following prolonged aerobic exercise.

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Co-ingestion of protein or a protein hydrolysate with carbohydrate enhances anabolic signaling, but not glycogen resynthesis, following recovery from prolonged aerobic exercise in trained cyclists

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