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Proteome organ aging and cardiometabolic risk in a population at risk for heart failure
Changes in body proteins with organ aging and heart-related health risks in people at risk for heart failure
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Abstract
Heart organ aging is associated with advanced heart failure (HF) severity, showing a significant relationship for both sexes.
- Heart organ aging was linked to advanced HF (Stage C/D) with odds ratios of 1.12 for women and 1.18 for men.
- Artery organ aging was associated with HF severity only in women, with an odds ratio of 1.10.
- Multi-organ aging (affecting two or more organs) increased the odds of being classified as Stage C/D by over three times.
- Heart organ aging correlated with impaired cardiac structure and function, including reduced ejection fraction in men and increased left ventricular mass index in both sexes.
- Diabetes was identified as a key factor influencing aging in both artery and kidney organs.
- Higher triglyceride-glucose body mass index (TyG-BMI) was significantly associated with advanced kidney organ aging in women.
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Key numbers
1.12
Increase in Odds of Advanced Stage C/D
for women with advanced heart
3×
Multi-organ Aging Impact on Stage
Odds increase for being in Stage C/D with multi-organ aging
1.88
Diabetes Impact on Kidney
for advanced kidney in women with diabetes