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Protein-based aging clocks in population studies: progress, uses, and future possibilities
Updated
Abstract
Essence
Proteomic aging clocks may help estimate biological aging and identify aging biomarkers, but clinical translation remains unsettled.
Evidence
This review summarizes human blood proteomic clock platforms, modeling strategies, and possible discovery, prediction, and response-biomarker applications.
Caveat
Proteomic clocks vary widely by assay platform, study population, and model, limiting generalizability, biological interpretability, and clinical utility.
Simplified
Longevity & Aging