No quick or lasting pain relief from one dose of psilocybin in three mouse pain models

Psilocybin showed no significant analgesic effects in various pain models tested in mice.

• The study evaluated the analgesic properties of psilocybin at doses of 0.3, 2, and 10 mg/kg.
• Behavioral assays for sensory and functional aspects of pain were conducted, including tests for inflammatory, neuropathic, and muscle pain.
• No significant analgesic effects were observed in response to psilocybin across different pain models and behavioral assessments.
• An apparent reduction in cold sensitivity was noted but may be attributed to hypothermia caused by psilocybin rather than true pain relief.

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