Psilocybin’s effects on loss of pleasure in unipolar and bipolar depression: A review of clinical and laboratory studies

Psilocybin may influence anhedonia outcomes in mood disorders.

• Anhedonia is a key feature of mood disorders linked to functional impairment and reduced quality of life.
• Psilocybin is being investigated as a new treatment option for major depressive disorder (MDD).
• Current research on psilocybin's effects on anhedonia has not been comprehensively reviewed.
• Available studies include both clinical and pre-clinical research on psilocybin's impact on anhedonia.

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