In vivo production of psilocybin in E. coli

A production titer of 1.16 g/L of psilocybin was achieved in a recombinant organism.

• The psilocybin production platform was developed in Escherichia coli.
• A 32-fold improvement in psilocybin production was observed through genetic optimization techniques.
• Fermentation optimization further enhanced production capabilities.
• This achievement is associated with the highest psilocybin titer reported from a recombinant organism to date.
• The findings suggest potential for industrial-scale production of biologically-derived psilocybin.

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