Long-term follow-up of psilocybin-facilitated smoking cessation

At 12 months, 67% of participants were confirmed as smoking abstinent after psilocybin treatment combined with cognitive behavioral therapy.

• A total of 15 participants completed a 12-month follow-up after receiving psilocybin for smoking cessation.
• At long-term follow-up (≥16 months), 60% of participants remained confirmed as smoking abstinent.
• The average time from the first psilocybin session to long-term follow-up was 30 months, with a range of 16 to 57 months.
• Most participants (86.7%) reported their psilocybin experiences as among the five most personally meaningful and spiritually significant encounters of their lives.
• The findings indicate that psilocybin may be effective in promoting long-term smoking cessation within a structured treatment framework.

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