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Abstract
Of 9,195 studies screened, 61 studies met eligibility criteria for systematic review on the immunomodulatory effects of serotonergic psychedelics.
- Most in vitro (19 out of 24) and non-human in vivo (25 out of 30) studies reported anti-inflammatory effects of psychedelics.
- Human results were mixed, with anti-inflammatory effects observed in 3 out of 10 trials.
- Meta-analysis of 18 in vivo murine studies showed a significant decrease in proinflammatory cytokines in inflammatory models (standardized mean difference = -1.23, 95% CI [-1.54, -0.92]).
- No significant effects were observed in healthy murines (standardized mean difference = -0.06, 95% CI [-0.54, 0.43]).
- Limited human evidence from four studies resulted in imprecise estimates, making it difficult to draw conclusions about the translational potential of these findings.
Simplified
Psychedelic Science