Journal of psychopharmacology (Oxford, England)

Psychedelics and psychosis: A review of recent studies from 1984 to 2025

Updated

Abstract

This review synthesizes evidence from studies (1984-2025) on the relationship between classical psychedelics and psychotic symptoms.

  • Classical psychedelic drugs may be associated with an increased risk of psychotic symptoms in certain individuals.
  • Risk factors for psychosis could include personal and family history of mental health issues.
  • The prevalence of psychosis related to psychedelic use varies across different populations and substances.
  • Clinical characteristics of psychedelics-related psychosis may differ from other forms of psychosis.
  • Findings aim to help clinicians and policymakers in identifying and mitigating risks linked to psychedelic use.

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