Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain–gut barriers

Feb 3, 2019The Journal of nutritional biochemistry

Puerariae Lobatae Root and Chuanxiong Rhizome may help treat stroke by changing gut bacteria to support brain-gut barriers

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Abstract

The combination of Puerariae Lobatae Radix (PLR) and Chuanxiong Rhizoma (CXR) effectively improved neurological function and reduced cerebral infarction in cerebral ischemic stroke.

Cerebral ischemic stroke is associated with disturbances in gut microbes, enriching harmful bacteria and increasing intestinal permeability.
Specific bacteria linked to stroke include Bacteroides, Escherichia_Shigella, and Klebsiella, while beneficial bacteria were diminished.
The combination of PLR and CXR may mitigate cerebral damage by remodeling gut microecology and increasing levels of protective bacteria.
PLR and CXR improved protective proteins in the gut barrier, potentially reducing the risk of microbial translocation to the brain.
Nimodipine did not alleviate gut microbiota dysbiosis and instead worsened gut barrier disruption.

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The combination of Puerariae Lobatae Radix (PLR) and Chuanxiong Rhizoma (CXR) is commonly used to treat cerebrovascular diseases. This work aimed to clarify the mechanisms of their action in treating cerebral ischemic stroke from the perspective of gut microecology. The PLR and CXR combination effectively improved the neurological function, reduced the cerebral infarction and relieved the complications of cerebral ischemic stroke, including dyslipidemia, increased blood viscosity and thrombotic risk. Cerebral ischemic stroke triggered gut microbial disturbances by enriching pathogens and opportunistic microorganisms, including Bacteroides, Escherichia_Shigella, Haemophilus, Eubacterium_nodatum_group, Collinsella, Enterococcus, Proteus, Alistipes, Klebsiella, Shuttleworthia and Faecalibacterium. Cerebral ischemic stroke also increased the intestinal permeability, disrupted the gut barrier and caused intestinal microbial translocation. Occludin, claudin-5 and ZO-1 levels in the brain-gut barriers showed a high positive correlation. However, the combination remodeled the gut microecology by modulating endogenous bacteria whose effects may mitigate cerebral damage, such as Alloprevotella, Ruminococcaceae, Oscillospira, Lachnospiraceae_NK4B4_group, Akkermansia and Megasphaera, protected the brain-gut barriers by increasing claudin-5 and ZO-1 levels; and weakened the gut microbiota translocation by decreasing diamine oxidase, lipopolysaccharide and d-lactate. Although nimodipine effectively reduced the cerebral infarction, it did not relieve the gut microbiota dysbiosis and instead aggravated the gut barrier disruption and microbiota translocation. In conclusion, cerebral ischemic stroke caused gut microbiota dysbiosis, increased intestinal permeability, disrupted the gut barrier and triggered gut microbiota translocation. The PLR and CXR combination was an effective treatment for cerebral ischemic stroke that relieved the gut microbiota dysbiosis and brain-gut barriers disruption.

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Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain–gut barriers

Abstract

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