Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents

Jun 3, 2020Archiv der Pharmazie

Pyrazole-coumarin and pyrazole-quinoline chalcones as possible new drugs against tuberculosis

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Abstract

Among 32 tested compounds, 3e, 3u, and 7h showed an MIC value of 3.125 µg/ml against Mycobacterium tuberculosis.

The synthesized pyrazole-coumarin and pyrazole-quinoline chalcones were characterized using various spectroscopic techniques.
Molecular docking studies suggested a probable mechanism of action through interaction with the enzyme DprE1.
Binding affinity values for the chalcone derivatives ranged from -7.047 to -9.353 kcal/mol.
The compounds demonstrated good pharmacological properties and oral absorption potential based on predicted ADME parameters.
Compounds 3e, 3u, and 7h were determined to be nontoxic in the assays conducted.

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Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole-coumarin chalcones and pyrazole-quinoline chalcones were synthesized using multiple-step reactions. All the synthesized compounds were well characterized using different spectroscopic techniques includingH andC nuclear magnetic resonance, high-resolution mass spectroscopy, and electrospray ionization-mass spectrometry. The compounds were evaluated for their antitubercular activity against the Mycobacterium tuberculosis H37Rv strain using the microplate Alamar Blue assay, and the minimal inhibitory concentrations (MIC) of the compounds were determined. Among the 32 tested compounds, compounds 3e, 3u, and 7h showed an MIC value of 3.125 µg/ml, and they were found to be nontoxic. Molecular docking studies of the compounds with the enzyme DprE1 revealed the probable mechanism of action. The chalcone derivatives exhibited binding affinity values between -7.047 and -9.353 kcal/mol. ADME parameters were predicted using the QikProp module of the Schrödinger software, and these compounds exhibited good pharmacological and oral absorption properties. 1 13

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Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents

Abstract

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