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Novel pyrazole‐clubbed thiophene derivatives via Gewald synthesis as antibacterial and anti‐inflammatory agents
New pyrazole-linked thiophene compounds made by Gewald synthesis as antibacterial and anti-inflammatory agents
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Abstract
Compounds 8b, 8c, 8f, 8g, 8k, 8n, and 8o exhibited promising antibacterial activity.
- Compounds were synthesized from 2-amino-5-(2,4-dichlorophenyl)thiophene-3-carbonitrile and 1,3-disubstituted-1H-pyrazole-4-carbaldehydes.
- In vitro screening demonstrated antibacterial and anti-inflammatory activities of the synthesized compounds.
- Compound 8a showed potential as an antitubercular agent against Mycobacterium tuberculosis H37Rv.
- Hemolytic assays indicated that the compounds are nontoxic, with hemolysis percentages between 3.6 and 20.1 at a concentration of 1 mg/ml.
- The substitution pattern on the pyrazole ring may influence the biological activity of the compounds.
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