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Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease
Qingyangshen reduces harmful protein buildup by activating cell cleanup pathways in a mouse model of Alzheimer's disease
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Abstract
Oral administration of Qingyangshen (QYS) extract improved learning and spatial memory in 3XTg AD mice.
- QYS extract reduced levels of carboxy-terminal fragments, amyloid precursor protein, amyloid β, and Tau aggregates in the brains of 3XTg mice.
- The treatment inhibited microgliosis and astrocytosis, which are associated with neuroinflammation in Alzheimer's disease.
- QYS extract increased the expression of two proteins, PPARα and TFEB, linked to cellular processes that may help clear cellular waste.
- The findings suggest that the neuroprotective effects of QYS may involve the enhancement of the autophagy-lysosomal pathway.
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