Protein changes that occur together as cells age and stop dividing

Proteome changes during cellular senescence are characterized by widespread protein depletion on chromatin.

• Cellular senescence leads to irreversible cell cycle arrest due to factors like telomere erosion and DNA damage.
• Senescent cells accumulate, disrupting tissue function and contributing to aging and disease.
• The depletion of proteins in the cytoplasmic translation machinery is observed during senescence.
• Mitochondrial proteins in senescent cells show increased insolubility.
• Autophagic and proteasome activities are compromised, along with changes in ubiquitin linkages and depletion of ubiquitin E3 ligases.
• A distinctive senescent proteome signature is identified, differing from other pathological cellular states.

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